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. 2021 Aug 27;10(9):2219. doi: 10.3390/cells10092219

Figure 3.

Figure 3

Putative structure of CNGC19 channel. (Top) Schematic cartoon representation of CNGC19 channel subunit showing six membrane-spanning regions (S1–S6) and a large pore domain (S5–S6). Functionally relevant sites in the C-terminus consist of a CNB, cyclic nucleotide-binding domain which can bind cAMP/cGMP, and a CaMBD, calmodulin-binding domain which can bind calmodulin. The functional channel is formed by four subunits. (Bottom) The structure of CNGC19 has not been solved to date but is likely to show similarities with the animal CNG family of channels. Therefore, the structure shown in the figure is an approximation based on homology to other channels. The predicted CNGC19 secondary 3D structure model, showing four subunits in transparent surface view, was developed from the closest homolog PDB structure, 5VA1 (human ether-a-go-go related K+ channel) using PHYRE 2.0 program. The image was prepared using Chimera software [122]. Created with BioRender.com (accessed on 30 August 2021).