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. 2021 Sep 9;10(9):2368. doi: 10.3390/cells10092368

Figure 1.

Figure 1

Gene networks and hub genes of the developing iWAT and BAT. (a) Hematoxylin and eosin (H&E) stained sections, and UCP1 immunostaining of BAT and iWAT at P6 and P56. Insets show periodic acid Schiff (PAS)-stained sections. Scale 50 μm. (b) Hierarchical clustering of samples. The closer the samples were to each other, the more similar their transcriptional landscapes were. (c) In assay 1, gene expression profiles of P6 and P56 iWAT were compared. (d) Volcano plot of DEGs. (e) Interactome map and most significant GO terms of DEGs overrepresented in P6 iWAT in assay 1. (f) Interactome map and most significant GO terms of underrepresented DEGs in P6 iWAT in assay 1. (g) In assay 2, gene expression profiles of P6 and P56 BAT were compared. (h) Volcano plot of DEGs. (i) Interactome map and most significant GO terms of DEGs overrepresented in P6 BAT in assay 1. (j) Interactome map and most significant GO terms of underrepresented DEGs in P6 BAT in assay 1. (k) In assay 3, gene expression profiles of P6 BAT and P6 iWAT were compared. (l) Volcano plot of DEGs. (m) Interactome map and most significant GO terms of DEGs overrepresented in P6 BAT in assay 3. (n) Interactome map and most significant GO terms of underrepresented DEGs in P6 BAT in assay 1. (o) In assay 4, gene expression profiles of P56 BAT and P56 iWAT were compared. (p) Volcano plot of DEGs. (q) Interactome map and most significant GO terms of DEGs overrepresented in P56 BAT in assay 4. (r) Interactome map and most significant GO terms of underrepresented DEGs in P56 BAT in assay 4.