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. 2021 Sep 10;13(18):4544. doi: 10.3390/cancers13184544

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Overview of metabolic-related therapeutic targets for the treatment of BC patients identified from multi-omics-based studies. α-KG: alpha-ketoglutarate, ACACA: acetyl-CoA carboxylase alpha, ADHFE1: alcohol dehydrogenase iron containing 1, CBX2: chromobox 2, CBX7: chromobox 7, CPT1: carnitine palmitoyltransferase 1A, CPT2: carnitine palmitoyltransferase 2, ECT: electron transport chain, ELOVL1: ELOVL fatty acid elongase 1, ELOVL2: ELOVL fatty acid elongase 2, FASN: fatty acid synthase, GLUT1: glucose transporter 1, HK: hexokinase, INSIG1: insulin-induced gene 1, LDH: lactate dehydrogenase, OXPHOS: oxidative phosphorylation, PDC: pyruvate dehydrogenase kinase, RRM2: ribonucleotide reductase regulatory subunit M2, SCAP: SREBF chaperone, SCD: stearoyl-CoA desaturase, TCA: tricarboxylic acid, THRSP: thyroid hormone-responsive. Created with BioRender.com.