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Benzydamine prevents the evolution of tigecycline resistance. (A) TIG resistance acquisition curves in the presence of sub-inhibitory concentration of TIG or a combination of BEN and TIG against novel temxCD-toprJ-harboring Gram-negative bacteria during 32 serial passages. (B) Mutant prevention concentrations (MPCs) of TIG in the presence of increasing concentrations of BEN against temxCD-toprJ-positive Gram-negative bacteria. Data are representative of three biological replicates.
