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Overview of key steps in the constraint-based modeling process. Extracting a context-specific model representing the metabolism of a tissue type or cell line requires several steps. The most salient steps consist of choosing the kind of generic model to use, the addition of the biomass function, how to constrain the uptake and secretion fluxes in the model, defining of the gene expression threshold to include a gene in a reaction and choosing the MEM algorithm to use for extraction.
