Table 3.
Three clinical trials of dietary supplementation with probiotics for the eradication of gut Enterobacterales carriage registered at ClinicalTrials.gov, as posted from July 2008 to July 2021.
| ClinicalTrials.gov Identifier | Official Title | First Posted | Study Design/Case Number | Probiotic Strain | Location | Outcome Measures | Status |
|---|---|---|---|---|---|---|---|
| NCT 00722410 | Safety and efficacy study of eradication of carbapenem- resistant Klebsiella pneumoniae from the gastrointestinal tract by probiotics | 25 July 2008 | Open-label, randomized/60 | VSL#3® 1 | Jerusalem, Israel | Negative stool culture for carbapenem-resistant Klebsiella pneumoniae | Not yet recruiting |
| NCT 03967301 | Prevention and decolonization of multidrug-resistant bacteria with probiotics | 30 May 2019 | Double-blinded, randomized/228 | Bioflora® 2 | Buenos Aires, Argentina | Risk of colonization and/or infection by carbapenem-resistant Enterobacterales | Not yet recruiting |
| NCT 04431934 | Open-label, randomized study to assess the efficacy of a probiotic or fecal microbiota transplantation (FMT) on the eradication of rectal multidrug-resistant Gram-negative bacilli (MDR-GNB) carriage (PROFTMDECOL) | 16 June 2020 | Open-label, randomized/437 | Vivomixx® 3 | Barcelona, Spain | Eradication of rectal multidrug-resistant Gram-negative bacilli carriage | Recruiting |
1VSL#3®: 4 Lactobacillus strains (L. acidophilus, L. plantarum, L. casei, and the L. delbrueckii subspecies bulgaricus), 3 Bifidobacterium strains (B. breve, B. longum, and B. infantis), and the S. salivarius subspecies thermophilus; 2 Bioflora®: L. casei, L. plantarum, S. faecalis, and B. brevis; 3 Vivomixx®: 4 Lactobacillus strains (L. paracasei 24733, L. acidophilus 24735, L. delbrueckii ssp bulgaricus 24734, and L. plantarum 24730), 3 Bifidobacterium strains (B. brief 24732, B. longum 24736, and B. infantis 24737), and S. thermophilus 24731.