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Representative Dixon plot obtained from an inhibition kinetic study of UGT1A1-mediated SN-38 glucuronidation in the presence of different concentrations of trans-resveratrol in pooled human liver microsomes (n = 3). An increasing concentration of SN-38 (0.5 (⬤), 2.0 (◯), and 10 μM (▼)) was incubated with HLMs (0.25 mg/mL) and UDPGA (1 h, 37 °C) in the presence or absence of trans-resveratrol (0, 0.5, 2.0, 5.0, 20, and 50 μM).
