Table 3.
Inhibitory effects (IC50 values) of trans- and cis-resveratrol against six uridine 5′-diphospho-glucuronosyltransferase isoforms (UGTs) in HLMs (n = 3).
| UGT Enzyme | Substrate * | Trans-Resveratrol | Cis-Resveratrol |
|---|---|---|---|
| 1A1 | SN-38 | 9.57 ± 1.60 | >50.0 |
| 1A3 | CDCA | >50.0 | >50.0 |
| 1A4 | TFP | >50.0 | >50.0 |
| 1A6 | N-ASER | >50.0 | >50.0 |
| 1A9 | MPA | >50.0 | >50.0 |
| 2B7 | Naloxone | >50.0 | >50.0 |
* SN-38: 7-Ethyl-10-hydroxycamptothecin; CDCA: Chenodeoxycholic acid; TFP: Trifluoperazine; N-ASER: N-Acetylserotonin, and MPA: Mycophenolic acid.