FIG. 2.

Identification of a NES-like sequence in RelA. The upper panel shows the amino acid sequence of the C-terminal region of RelA mediating its cytoplasmic distribution. The NES-like sequence is indicated. The lower panel shows the sequence homology of the RelA NES with the NES characterized from various other proteins, including the alpha and beta subunits of the protein kinase inhibitor (PKI) (57), the HIV Rev protein (18), and c-Abl (52). The four hydrophobic amino acids, most of which are leucines, are bold and underlined. The NES of RelA is located between amino acids 436 and 445.