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. 2021 Aug 31;11(9):1295. doi: 10.3390/biom11091295

Figure 1.

Figure 1

Cur inhibits CRC cell growth and attenuates NNMT-induced resistance to 5-FU. (A,D) CCK-8 analysis of HT-29/NC, HT-29/shNNMT, SW480/NC, and SW480/NNMT cell viability following treatment with Cur for 24 h. (B,E) CCK-8 analysis of HT-29/NC, HT-29/shNNMT, SW480/NC, and SW480/NNMT cell viability following treatment with Cur combined with different concentrations of 5-FU for 24 h. (C,F) IC50 of 5-FU when co-treated with or without Cur in HT-29/NC, HT-29/shNNMT, SW480/NC, and SW480/NNMT displayed as a histogram. 5-FU: 5-Fluorouracil, Cur: curcumin. Data are expressed as means ± SD, n = 3, * p < 0.05, ** p < 0.01.