Table 3.

Key residues of HMGCR active sites interacting with the ligands.

PDB Entry	Site	Naringenin	Hesperetin
1HW8	1	Lys735 B	Ser684 A, Lys735 B
	2	Lys735 A	Glu559 A, Lys735 A
	3	Lys735 D	Glu559 D, Glu665 C, Glu665 C, Lys735 D, Lys691 C
	4	Lys735 C	Lys735 C
1HW9	1	Lys735 B, Asn755 B	Ser684 A, Lys735 B
	2	Glu559 A, Lys735 A, Ser684 B, Lys691 B	Glu559 A, Lys735 A, Ser684 B, Lys691 B
	3	Glu665 C, Lys735 D	Glu665 C, Ser684 C, Lys735 D
	4	Glu665 D, Lys735 C	Lys735 C, Ser684 D, Asn755 C
1HWI	1	Lys735 B, Asn755b	Glu559 B, Ser684 A, Lys735 B
	2	Ala751 A, Glu665 B, Lys735 A	Glu665 B, Lys735 A
	3	Ala751 D, Ser684 C, Lys735 D	Ala751 D, Ser684 C, Lys735 D
	4	Lys735 C, Ser661 D	Lys735 C
1HWJ	1	Lys735 B	Lys735 B
	2	Lys735 A	Lys735 A, Ser684 B
	3	Lys735 D	Lys735 D
	4	Glu665 D, Lys735 C	Glu559 C, Lys735 C, Lys691 D
1HWK	1	Glu665 A, Lys735 B	Ser684 A, Lys735 B
	2	Glu559 A, Glu665 B, Lys735 A, Lys691 B	Glu665 B, Lys735 A, Ser684 B
	3	Ala751 D, Lys735 D, Asn755 D	Lys735 D
	4	Glu665 D, Lys735 C	Glu559 C, Lys735 C, Lys691 D
1HWL	1	Ser684 A, Lys735 B	Glu559 B, Ser684 A, Lys735 B
	2	Lys735 A, Ser684 B	Lys735 A, Ser684 B
	3	Ser684 C, Lys735 D	Lys735 D
	4	Lys735 C, Ser684 D	Glu559 C, Glu665 D, Lys735 C, Ser684 D