Table 3.
Liposomes | Liposomal Formulation |
PS | Light Dose | Tumor Type | Outcomes | Ref | |
---|---|---|---|---|---|---|---|
Tetraether liposomes | DSPC TELs |
Curcumin | 13.2 J/cm2 | Ovarian cancer (SK-OV-3) |
|
[59] | |
DSPC TELs |
Curcumin | 1, 3, and 5 J/cm2 | Papillomavirus-related cancer cell lines | Enhanced cytotoxicity, reduced colony formation, proliferation, and cell migration rates. | [60] | ||
DPPC TELs |
Hypericin | 12.4 J/cm2 | SK-OV-3 |
|
[61] | ||
TELs | Protoporphyrin IX | 672 mJ/cm2 | SK-OV-3 |
|
[63] | ||
DPPC TELs |
Temoporfin (mTHPC) |
10 J/cm2 | SK-OV-3 |
|
[64] | ||
Stealth Liposomes | DPPC DPPE-mPEG5000 |
Temoporfin (mTHPC) |
10 J/cm2 | SK-OV-3 |
|
[64] | |
HSPC DPPE mPEG5000 |
Curcumin | 2.5 J/cm2 | Skin cancer melanoma cells (MUG-Mel2) and squamous cell carcinoma (SCC-25) |
|
[66] | ||
DPPC DSPC: DPPE mPEG5000 |
mTHPC | 5 and 10 J/cm2 | SK-OV-3 | Enhanced cytotoxicity on cancer cells. | [67] | ||
DPPC DOTAP |
Lapatinib | 65 (mW/cm2) | Human glioblastoma cancer cell lines (U87, U87vIII) | Remarkable reduction in the LD50. | [68] | ||
DSPC DSPE-PEG2000 Cholesterol |
Chlorin e6 | 100 J/cm2 | C26 colon cancer cells |
|
[69] | ||
DSPC DPPE mPEG5000Cholesterol |
Chlorin e6 | 95 mW/cm2 | Malignant peripheral nerve sheath cancer |
|
[70] | ||
Thermosensitive liposomes |
DPPC SoyPC Chol DSPE-PEG 2000 |
ICG | 14 J/cm2 | Triple-negative breast cancer (MDA-MB-468 and HCC-1806 cells) | Significant cytotoxicity compared to free PS | [81] | |
DPPC DPPG DPPE mPEG5000 |
IR820 | 2.5 W/cm2 | mouse fore-stomach carcinoma cell (MFC) | Significant cytotoxicity | [82] | ||
Miscellaneous Liposomes | Lipopolyplexes (LPPs) | DOPC DPPC Cholesterol |
Curcumin | 1 J/cm2 | SK-OV-3 |
|
[86] |
Magnetic/photo-responsive liposomes | DSPC Cholesterol DDAB |
Indocyanine green (ICG) | 2 J/cm2 | Glioblastoma cancer cells (U87MG) | Significant cytotoxicity and accumulation in cancer cells. | [87] | |
Chitosan-coated liposomes | DMPC Cholesterol |
ICG | 250 mW | Melanoma | Improved permeability and phototoxicity. | [89] | |
Zwitterionic liposomes | Poly-(12-meth-acryloyloxy)-dodecyl phosphoryl-choline DSPC |
Methylene blue (MB) | 165 mW | Breast cancer cells (4T1 cells) |
|
[90] |