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Tumor-specific CPP-conjugate delivery strategies. To additionally improve intracellular uptake of conjugates via CPPs, cargos can be conjugated to either tumor-homing CPPs (A), tumor-homing moiety (B) or a specific antibody for a membrane receptor (C). CPPs can enter any kind of cell, but the cargo is only active inside tumorous cells where molecular pathways are deregulated (D). CPP-based drugs can be activated in the proximity of the tumor microenvironment (E).
