Table 1. Baseline, Laboratory, and Angiographic Characteristics according to HLI at ER (ER AST >80) and HH (Peak AST and/or ALT >800).
| Variable | Total (n=1537) |
HLI at ER (−) HH (−) (n=1185) |
HLI at ER (+) HH (−) (n=321) |
HLI at ER (−) HH (+) (n=14) |
HLI at ER (+) HH (+) (n=17) |
p value | |
|---|---|---|---|---|---|---|---|
| Age (yr) | 60.5±13.2 | 60.5±13.0 | 60.8±13.8 | 59.4±14.9 | 63.9±14.5 | 0.714 | |
| Male sex | 79.2 | 79.5 | 77.9 | 78.6 | 88.2 | 0.742 | |
| Diabetes | 27.1 | 27.7 | 24.0 | 28.6 | 41.2 | 0.321 | |
| Hypertension | 48.6 | 49.4 | 44.9 | 57.1 | 58.8 | 0.362 | |
| Dyslipidemia | 19.6 | 20.5 | 17.1 | 21.4 | 5.9 | 0.272 | |
| SBP (mm Hg) | 124.0±30.1 | 125.0±29.8 | 121.7±30.7 | 116.4±31.7 | 106.9±28.7 | 0.024 | |
| DBP (mm Hg) | 75.9±19.1 | 76.3±18.6 | 75.2±20.6 | 73.9±23.3 | 63.8±15.4 | 0.048 | |
| Heart rate (bpm) | 77.7±21.4 | 76.4±20.5 | 81.6±23.6 | 82.3±19.5 | 94.0±26.8 | <0.001 | |
| Killip class | <0.001 | ||||||
| 1 | 77.6 | 80.3 | 70.8 | 64.3 | 35.3 | ||
| 2 | 7.1 | 7.3 | 6.6 | 14.3 | 0 | ||
| 3 | 6.8 | 5.8 | 10.4 | 7.1 | 11.8 | ||
| 4 | 7.8 | 6.1 | 11.3 | 14.3 | 52.9 | ||
| AST (mg/dL) | 70.2±133.3 | 31.8±14.8 | 183.3±135.6 | 33.9±9.7 | 646.2±775.8 | <0.001 | |
| ALT (mg/dL) | 39.1±56.4 | 26.4±14.1 | 74.4±57.5 | 28.6±20.0 | 266.5±363.3 | <0.001 | |
| Peak AST (mg/dL) | 176.2±533.1 | 106.6±136.9 | 242.8±165.9 | 1102.0±595.2 | 3012.3±3913.0 | <0.001 | |
| Peak ALT (mg/dL) | 71.0±315.5 | 40.4±35.5 | 100.8±272.6 | 344.6±365.3 | 1417.8±2406.0 | <0.001 | |
| Initial CK (U/L) | 495.8±1059.3 | 227.5±386.9 | 1421.2±1850.8 | 212.2±185.0 | 1872.7±1797.6 | <0.001 | |
| Initial CK-MB (μg/mL) | 46.9±187.5 | 23.5±134.4 | 129.4±302.9 | 23.9±52.5 | 141.7±121.1 | <0.001 | |
| Initial TnI (ng/mL) | 11.27±51.22 | 5.22±24.20 | 26.28±56.41 | 4.72±14.28 | 135.10±366.92 | <0.001 | |
| Peak CK (U/L) | 1881.8±2729.3 | 1460.7±2152.5 | 2872.6±3168.4 | 4737.4±5859.4 | 7814.9±7804.0 | <0.001 | |
| Peak CK-MB (μg/mL) | 214.9±264.2 | 190.6±210.7 | 283.4±383.7 | 457.7±265.0 | 421.0±435.7 | <0.001 | |
| Peak TnI (ng/mL) | 60.91±111.35 | 56.23±109.43 | 69.55±80.92 | 64.05±71.77 | 184.90±397.07 | 0.802 | |
| LVEF (%) | 48.4±12.1 | 49.6±11.6 | 45.9±11.9 | 30.7±11.6 | 28.7±18.3 | <0.001 | |
| CAD extent | 0.946 | ||||||
| One-vessel disease | 39.8 | 40.3 | 37.9 | 35.7 | 41.2 | ||
| Two-vessel disease | 33.4 | 32.9 | 35.7 | 28.6 | 29.4 | ||
| Three-vessel disease | 26.8 | 26.8 | 26.3 | 35.7 | 29.4 | ||
| Multi-vessel disease | 38.0 | 37.5 | 40.1 | 35.7 | 35.3 | 0.846 | |
| Infarct-related artery | 0.008 | ||||||
| LAD | 50.9 | 50.6 | 51.1 | 64.3 | 52.9 | ||
| LCX | 10.6 | 10.7 | 10.3 | 14.3 | 5.9 | ||
| RCA | 37.4 | 38.0 | 36.7 | 14.3 | 29.4 | ||
| LMCA | 1.2 | 0.8 | 1.9 | 7.1 | 11.8 | ||
| IABP | 3.7 | 3.0 | 7.1 | 7.1 | 18.8 | 0.002 | |
| STB (min) | 430.3±1545.3 | 368.0±1593.7 | 675.2±1404.2 | 162.7±136.2 | 346.5±517.2 | 0.016 | |
| Temporary pacemaker | 6.7 | 6.9 | 6.6 | 0 | 6.3 | 0.789 | |
| In-hospital mortality | 5.7 | 3.1 | 11.8 | 28.6 | 47.1 | <0.001 | |
AST, aspartate transaminase; ALT, alanine transaminase; CAD, coronary artery disease; CK, creatine kinase; CK-MB, creatine kinase-myocardial band; DBP, diastolic blood pressure; ER, emergency room; HH, hypoxic hepatitis; HLI, hypoxic liver injury; IABP, intra-aortic balloon pump; LAD, left anterior descending artery; LCX, left circumflex artery; LMCA, left main coronary artery; LVEF, left ventricular ejection fraction; RCA, right coronary artery; SBP, systolic blood pressure; TnI, troponin I; STB, symptom to balloon time.
Data are expressed as percentage or means±standard deviations.