Table 3.
Predicted HTL epitopes from S. aureus cell wall adherence proteins, SdrD and SdrE to design a multi-epitope vaccine construct with their corresponding MHC Class II alleles and their immunogenic properties.
| Uniprot_ID | MHC II Epitope | Alleles | Position | IC50 Value | Percentile Rank | Antigenicity Score | Toxicity | Hydrophobicity | Hydropathicity | Hydrophilicity | Charge | Mol. wt. |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| O86488 | KRLNTRMRIAAVQPS | HLA-DQA1*01:02, HLA-DQB1*06:02, HLA-DPB1*01:01, HLA-DRB1*01:01, HLA-DRB1*09:01,HLA-DRB3*02:02, HLA-DRB1*13:02, HLA-DRB1*11:01, HLA-DRB1*04:01, HLA-DRB1*12:01, HLA-DPA1*03:01, HLA-DPB1*04:02, HLA-DRB1*04:05, HLA-DRB1*15:01, HLA-DQA1*01:01, HLA-DQB1*05:01, HLA-DRB1*08:02, HLA-DPA1*02:01, HLA-DPB1*14:01, HLA-DPA1*01:03, HLA-DPB1*04:01, HLA-DQA1*05:01, HLA-DQB1*03:01, HLA-DQA1*04:01, HLA-DQB1*04:02, HLA-DPA1*02:01, HLA-DPA1*02:01, HLA-DPB1*05:01, HLA-DPA1*01:03, HLA-DPB1*02:01, HLA-DQA1*05:01, HLA-DQB1*02:01, HLA-DQA1*03:01, HLA-DQB1*03:02, HLA-DRB3*01:01, HLA-DRB5*01:01, HLA-DRB1*07:01, HLA-DRB4*01:01, HLA-DRB1*03:01 | 226–240 | 30 | 0.11 | 0.9801 | Non-toxin | −0.38 | −0.63 | 0.33 | 4 | 1741.3 |
| O86489 | DTEFTIDNKVKKGDT | HLA-DRB1*03:01, HLA-DRB3*01:01, HLA-DPA1*03:01, HLA-DPB1*04:02, HLA-DPA1*01:03, HLA-DPB1*02:01,HLA-DRB1*01:01, HLA-DRB1*09:01,HLA-DRB3*02:02, HLA-DRB1*13:02, HLA-DRB1*11:01, HLA-DRB1*04:01, HLA-DRB1*12:01,HLA-DRB1*04:05, HLA-DRB1*15:01, HLA-DQA1*01:01, HLA-DQB1*05:01, HLA-DRB1*08:02, HLA-DPA1*02:01, HLA-DPB1*14:01, HLA-DPA1*01:03, HLA-DPB1*04:01, HLA-DQA1*05:01, HLA-DQB1*03:01, HLA-DQA1*04:01, HLA-DQB1*04:02, HLA-DPA1*02:01, HLA-DPB1*01:01, HLA-DPA1*02:01, HLA-DPB1*05:01,HLA-DQA1*05:01, HLA-DQB1*02:01, HLA-DQA1*03:01, HLA-DQB1*03:02, HLA-DQA1*01:02, HLA-DQB1*06:02, HLA-DRB5*01:01, HLA-DRB1*07:01, HLA-DRB4*01:01, | 312–326 | 88 | 0.88 | 1.2192 | Non-toxin | −0.35 | −1.35 | 0.95 | −1 | 1711.07 |