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Inhibitory activities of 5a’-carbadisaccharides 1–4 against α2,3- and α2,6-STs (Data from [106]).
| # | Inhibitory Activitiesa (IC50, μM) | |
|---|---|---|
| α2,6-ST (rST6Gal-I) | α2,3-ST (rST3Gal-I) | |
| 1 | 903 | 419 |
| 2 | 533 | 185 |
| 3 | 651 | 245 |
| 4 | >1 mM | >1 mM |
a 4-methylumbellipheryl LacNAc was used as the substrate with Michaelis-Menten constant (Km) values of 264 μM and 233 μM for α2,3- and α2,6-STs, respectively.
