Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Inhibition of α2,6-(N)-ST and α2,3-(O)-ST by homolactones 103–105 and homolactams 106–108 (Data from [176]).
| Compound | # | α2,6-(N)-ST (hST6Gal-I) | α2,3-(O)-ST (rST3Gal-I) | ||
|---|---|---|---|---|---|
| IC50, μM | % Inhibition at 3 μM | IC50, μM | % Inhibition at 100 μM | ||
|
103 | ~3.0 | 50 | >100 | 0 |
|
104 | >3.0 | 44 | >100 | 0 |
|
105 | <3.0 | 54 | >100 | 0 |
|
106 | <3.0 | 57 | >100 | 0 |
|
107 | - | 30 | >100 | 0 |
|
108 | - | 30 | >100 | 0 |
