Table 2.
Photosensitizers under clinical trials for use in PDT.
| Trade Name | Molecular Formula | Excitation Wavelength (nm) |
Quantum Yield | Molar Extinction Coefficient (M−1 cm−1) |
Main Applications |
|---|---|---|---|---|---|
| Radachlorin® (chlorine) |
C34H36N4O6 C33H34N4O5 C33H34N4O6 |
662 | 0.52–0.62 | 3.42 × 104 | Skin cancer |
| Photochlor® (chlorins) |
C39H48N4O4 | 664 | 0.48 in CH2Cl2 | 4.75 × 104 in 1% Tween-80 micelles | Head and neck cancer |
| Purlytin® (purpurin) |
C37H42Cl2N4O2Sn | 664 | 0.7 in acetonitrile | 2.8 × 104 | Age-related macular degeneration |
| Fotolon® (chlorin) |
C34H36N4O6 | 665 | 0.63 in dimethylformamide | 5.0 × 104 in diethyl ether | Nasopharyngeal sarcoma |
| Lutrin® (texaphyrin) |
C52H72LuN5O14 | 732 | 4.2 × 104 in methanol | 0.11 in methanol | Coronary artery disease |
| TOOKAD® (WST09) (bacteriochlorin) |
C37H41K2N5O9PdS | 762 | 0.99 in organic solvent | 8.85 × 104 | Prostate cancer |