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. 2021 Sep 15;9(9):1229. doi: 10.3390/biomedicines9091229

Figure 1.

Figure 1

Cisd2 improves age-related fat accumulation and ameliorates the pathological abnormalities associated with natural aging. (A) Schematic representation of the study design used for liver proteome profiling. (B) Body weight, liver weight and the ratio of liver/body weight of the young WT mice (3-mo WT), old WT mice (26-mo WT) and old Cisd2TG mice (26-mo Cisd2TG) (n = 6 in each group). (C) Representative images of gross views of livers from the three groups. (D) Representative images of Oil Red O staining, IHC staining of glutamine synthetase (GS) and H&E staining of liver sections prepared from samples from the three mice groups. Hepatic steatosis around the central veins can be seen in the livers of the 26-mo WT mice. The data are presented as the means ± SD; * p < 0.05; ** p < 0.01 (Tukey’s HSD test after the one-way ANOVA had reached statistical significance). P, portal vein; C, central vein; n.s., non-significant.