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. 2021 Sep 15;9(9):1229. doi: 10.3390/biomedicines9091229

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Age-related alterations in various biological processes and cellular compartments were attenuated in the livers of the Cisd2TG mice. Overrepresentation analysis (ORA) of the 517 DEPs during natural aging and the 319 DEPs reversed by Cisd2TG; this was carried out using PANTHER GO. (A) Biological process analysis. (B) Cellular compartment analysis. The common enriched GO terms between 26-mo WT vs. 3-mo WT mice and 26-mo Cisd2TG vs. 26-mo WT mice were identified and manually grouped into five or seven annotated cellular functions. The horizontal axis shows the numbers of aging-associated DEPs in each annotated cellular function. The aging-associated DEPs are labeled in orange, and the DEPs reversed by Cisd2TG are labeled in blue. The percentage in blue represents the coverage of the Cisd2-associated proteins in the aging-associated DEPs.