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Modified Thomas plot [38]. Characterization (A) and monitoring (B) of anemia based on reticulocyte hemoglobin and the sTfR/log ferritin index. In (B), an initial functional iron deficiency (1) is first treated with ESA and i.v. iron therapy (2). Subsequent focus on ESA therapy leads to reduction of storage iron to a borderline level, while hemoglobinization of reticulocytes is still normal (3), Ret-Hb = Ret-He = mean reticulocyte hemoglobin.
