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. 2021 Sep 16;13(9):1484. doi: 10.3390/pharmaceutics13091484

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Correlation between permeability (Papp) data of drugs tested in in vitro rat BBB model, in vitro monkey BBB model, and mouse in vivo model. (a) Correlation between permeability of drugs in the apical to basolateral (A-B) tested at rat BBB model and monkey BBB model; (b) Correlation between permeability of drugs in the basolateral to apical (B-A) tested at rat BBB model and monkey BBB model; (c) Correlation between permeability of drugs tested at monkey BBB model (Papp in vitro) and the permeability of the same drugs measured in animal models (Papp in vivo).