Table 1.

Activities of compounds 7–22 against P. falciparum NF54, and L-6 cells, expressed as IC₅₀ (µM) ^a.

Compound	P.f. NF54 b IC50 (µM)	S.I. = IC50 (Cyt.)/IC50 (P.f. NF54)	Cytotoxicity L-6 Cells IC50 (µM)
7	15.98	15.98	144.0
8	6.09	9.52	57.97
9	7.05	7.86	55.43
10	5.34	17.29	92.31
11	2.51	13.57	34.07
12	2.92	7.64	22.30
13	23.60	3.86	91.10
14	5.12	9.56	48.96
15	2.68	46.27	124.0
16	0.743	318.3	236.5
17	0.464	208.8	96.86
18	0.644	273.3	176.0
19	1.04	238.9	248.5
20	2.00	59.70	119.4
21	1.26	137.6	173.4
22	0.324	168.9	54.73
CQ	0.0039	23,313	90.92
POD			0.012

CQ = chloroquine; POD = podophyllotoxin. ^a values represent the average of four determinations (two determinations of two independent experiments); ^b sensitive to chloroquine.