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. 2021 Sep 21;10(9):2502. doi: 10.3390/cells10092502

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© 2021 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Main sex differences in the regulation of healthy liver accounting for sex differences in NAFLD susceptibility. Arrows represent the relative regulation between males (blue) and females (red). With respect to men, women display decreased visceral adipose tissue lipolysis, limited FA uptake and DNL, restrained lipid storage and inflammation and enhanced FAO and lipid secretion. Abbreviations: DNL, de novo lipogenesis; FA, fatty acids; FAO, fatty acids oxidation; FFA, free fatty acids; ROS, reactive oxygen species; TG, triglycerides; VLDL-TG, very-low density lipoproteins—triglycerides; WAT, white adipose tissue.