Figure 2.

Summary of NOXs localization and NOX-dependent redox signaling through ROS. NOX1 is involved in survival pathways by EGFR and found in endosomes and nuclear membrane. NOX2 is found in the endoplasmic reticulum, endosomes and nuclear membrane, associated with the cytoskeleton. NOX2 is also associated, along with NOX4, to the plasma membrane and near the focal adhesions, regulating cell adhesion. Finally, NOX4 also mediates actin polymerization from the ER, as well as survival signaling when located in MAMs. In the mitochondria, it acts as an energetic sensor, and in the nuclei, is known to produce ROS in the perinuclear and nuclear space. Figure was created with BioRender.com (accessed on 12 July 2021).