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. 2021 Sep 3;10(9):2312. doi: 10.3390/cells10092312

Figure 3.

Figure 3

TGF-β signaling in liver cells. TGF-β is synthesized by hepatic stellate cells, kupffer cells and platelets, and anchored to the ECM in a latent form. Once active, TGF-β binds TGFβRII, which recruits TGFβRI, inducing Smad phosphorylation and nuclear translocation, where transcription of target genes occurs. TGF-β-induced shedding of the EGF family of growth factors requires the activation of TACE/ADAM17 in a Caveolin-1/Src/NOX1 dependent manner. Figure was created with BioRender.com (accessed on 20 July 2021).