Table 1.
Ingenuity Pathway Analysis-based profiles of ROS generation, glucose metabolism disorder, and ATP synthesis related factors of HEK293 cells treated with MNPs@SiO2(RITC).
| Entrez Gene Name | Symbol | ID b | Location | Signal Fold Change a | |
|---|---|---|---|---|---|
| 0.1 μg/μL | 1.0 μg/μL | ||||
| albumin | ALB | 1565228_s_at | Extracellular Space | 5.50 | 4.16 |
| apolipoprotein A1 | APOA1 | 217073_x_at | Extracellular Space | −3.75 | −1.53 |
| apolipoprotein E | APOE | 203382_s_at | Extracellular Space | 5.13 | 3.38 |
| ATP synthase F1 subunit gamma | ATP5F1C | 214132_at | Cytoplasm | −6.06 | −1.28 |
| BCL2 apoptosis regulator | BCL2 | 203684_s_at | Cytoplasm | −10.46 | −7.26 |
| BCL2 like 11 | BCL2L11 | 208536_s_at | Cytoplasm | 6.37 | 1.70 |
| catalase | CAT | 215573_at | Cytoplasm | 17.41 | 13.38 |
| CD44 molecule (Indian blood group) | CD44 | 234411_x_at | Plasma Membrane | 11.38 | −4.89 |
| complement C4A (Rodgers blood group) | C4A/C4B | 208451_s_at | Extracellular Space | −20.71 | 9.05 |
| cytochrome P450 family 19 subfamily A member 1 | CYP19A1 | 1554296_at | Cytoplasm | 15.56 | −17.51 |
| cytochrome P450 family 2 subfamily C member 9 | CYP2C9 | 214419_s_at | Cytoplasm | −3.60 | 1.19 |
| cytochrome P450 family 2 subfamily E member 1 | CYP2E1 | 209976_s_at | Cytoplasm | 18.60 | 3.69 |
| epidermal growth factor receptor | EGFR | 1565484_x_at | Plasma Membrane | 9.62 | 9.52 |
| erythropoietin | EPO | 207257_at | Extracellular Space | 8.02 | 8.34 |
| fatty acid binding protein 3 | FABP3 | 214285_at | Cytoplasm | −3.13 | −4.84 |
| fibronectin 1 | FN1 | 214702_at | Extracellular Space | −4.96 | 1.89 |
| fms related receptor tyrosine kinase 1 | FLT1 | 210287_s_at | Plasma Membrane | −10.50 | −3.85 |
| glutaminase | GLS | 203158_s_at | Cytoplasm | −14.49 | −2.26 |
| HNF1 homeobox A | HNF1A | 216930_at | Nucleus | −4.21 | 1.60 |
| insulin like growth factor 1 receptor | IGF1R | 243358_at | Plasma Membrane | −4.50 | −1.44 |
| integrin subunit beta 3 | ITGB3 | 215240_at | Plasma Membrane | 5.79 | 5.93 |
| interferon alpha and beta receptor subunit 1 | IFNAR1 | 204191_at | Plasma Membrane | −5.46 | 1.37 |
| Jun proto-oncogene, AP-1 transcription factor subunit | JUN | 201465_s_at | Nucleus | 7.34 | 1.43 |
| microtubule associated protein tau | MAPT | 203930_s_at | Plasma Membrane | −8.28 | −1.43 |
| myocyte enhancer factor 2D | MEF2D | 225641_at | Nucleus | −11.89 | −3.92 |
| nuclear receptor subfamily 3 group C member 1 | NR3C1 | 232431_at | Nucleus | 4.01 | −1.09 |
| nuclear receptor subfamily 4 group A member 1 | NR4A1 | 211143_x_at | Nucleus | 11.14 | 4.23 |
| nucleotide binding oligomerization domain containing 2 | NOD2 | 220066_at | Cytoplasm | 9.56 | 7.03 |
| peroxisome proliferator activated receptor alpha | PPARA | 1560981_a_at | Nucleus | −4.81 | 6.60 |
| peroxisome proliferator activated receptor delta | PPARD | 210636_at | Nucleus | 15.79 | 7.90 |
| phosphatase and tensin homolog | PTEN | 240964_at | Cytoplasm | −24.40 | 4.66 |
| promyelocytic leukemia | PML | 239582_at | Nucleus | −5.15 | 1.31 |
| protein kinase C alpha | PRKCA | 215195_at | Cytoplasm | 3.53 | 2.76 |
| protein kinase C beta | PRKCB | 227824_at | Cytoplasm | 6.41 | −10.37 |
| pyruvate kinase L/R | PKLR | 207858_s_at | Cytoplasm | 3.38 | 1.11 |
| solute carrier family 1 member 2 | SLC1A2 | 217055_x_at | Plasma Membrane | −11.34 | −8.32 |
| solute carrier family 2 member 2 | SLC2A2 | 206535_at | Plasma Membrane | 26.34 | 1.90 |
| solute carrier family 2 member 4 | SLC2A4 | 206603_at | Plasma Membrane | −5.42 | 3.00 |
| solute carrier family 7 member 11 | SLC7A11 | 217678_at | Plasma Membrane | 5.61 | 2.00 |
| somatostatin receptor 1 | SSTR1 | 235591_at | Plasma Membrane | −29.18 | −1.32 |
| SRC proto-oncogene, non-receptor tyrosine kinase | SRC | 1558210_at | Cytoplasm | −33.92 | −12.56 |
| synuclein alpha | SNCA | 236081_at | Cytoplasm | 3.22 | −1.89 |
| 3-hydroxybutyric acid | 300-85-6 | Other | −1.49 | −1.39 | |
| acetoacetic acid | 541-50-4 | Other | −1.40 | −1.40 | |
| citric acid | 77-92-9 | Other | −1.39 | −1.27 | |
| glycine | 56-40-6 | Other | −1.53 | −1.07 | |
| asparagine | 70-47-3 | Other | −1.21 | 1.01 | |
| aspartic acid | 56-84-8 | Other | −1.22 | −1.12 | |
| cysteine | 52-90-4 | Other | −1.24 | 1.09 | |
| glutamic acid | 56-86-0 | Other | 1.50 | 1.24 | |
| glutamine | 56-85-9 | Other | −1.89 | −1.51 | |
| leucine | 61-90-5 | Other | 1.38 | 1.28 | |
| lysine | 56-87-1 | Other | 1.91 | 1.25 | |
| serine | 56-45-1 | Other | −1.97 | 2.12 | |
| tyrosine | 60-18-4 | Other | 1.21 | −1.09 | |
| lignoceric acid | 557-59-5 | Other | 1.33 | 1.21 | |
| oxalacetic acid | 328-42-7 | Other | −1.47 | −1.32 | |
| pyruvic acid | 127-17-3 | Other | 1.41 | −6.13 | |
| succinic acid | 110-15-6 | Other | −2.28 | −1.21 | |
a Fold change of normalized signal in MNPs@SiO2(RITC)-treated group relative to corresponding control group. b ID for identifying the factors: Affymetrix probe ID for genes and CAS Registry Number or PubChem CID for metabolite. The data were reproduced from our previous studies, Copyright © 2021, American Chemical Society and Copyright © 2021, Shin et al. [18,28].