Table 1.
Patient characteristics for all included patients, patients with and without AKI.
| Variable | All Patients | Patients with AKI | Patients without AKI | |||
|---|---|---|---|---|---|---|
| N | Value | N | Value | N | Value | |
| Demographics | ||||||
| Age years, median (IQR) | 339 | 77.6 (70.6; 84.4) | 33 | 75.9 (72.3; 83.0) | 306 | 77.9 (70.5; 84.5) |
| Female, n (%) | - | 212 (62.5) | - | 25 (75.8) | - | 187 (61.1) |
| Body-mass index, median (IQR) | 304 | 25.1 (22.3; 28.8) | 26 | 24.8 (20.7; 28.9) | 278 | 25.1 (22.5; 28.8) |
| Hospitalization-days, median (IQR) | 339 | 2 (1; 6) | 33 | 7 (4; 13) | 306 | 2 (1; 5) |
| 30-day morality, n (%) | 339 | 12 (3.5) | 33 | 3 (9.1) | 306 | 9 (2.9) |
| Comorbidities | ||||||
| Cardiovascular disease (%) | - | 113 (33.3) | - | 12 (36.4) | - | 101 (33.0) |
| Diabetes (%) | - | 57 (16.8) | - | 5 (15.2) | - | 52 (17.0) |
| Medication | ||||||
| Total number of medications, median (IQR) | 339 | 6 (3; 9) | 33 | 8 (4; 12) | 306 | 6 (3; 9) |
| Biomarkers * | ||||||
| Creatinine µmol/L, median (IQR) | 339 | 84.3 (66.2; 105.4) | 33 | 120.8 (91.1; 169.5) | 306 | 83.0 (65.4; 100.2) |
| Cystatin C mg/L, median (IQR) | 339 | 1.21 (0.95; 1.60) | 1.69 (1.26–2.56) | 306 | 1.17 (0.94; 1.56) | |
| eGFR mL/min/1.73 m2, median (IQR) | 339 | 65.6 (48.2; 81.9) | 33 | 39.1 (26.7; 59.2) | 306 | 67.4 (50.7; 82.3) |
| CRP-µg/mL, median (IQR) | 314 | 15.5 (3.0; 63.7) | 33 | 67.0 (22.3; 120.3) | 281 | 14.0 (3.0; 53.4) |
| IL6-pg/mL, median (IQR) | 336 | 4.6 (1.9; 13.3) | 33 | 9.8 (3.6; 30.4) | 303 | 4.3 (1.8; 11.1) |
| TNF-α–pg/mL, median (IQR) | 336 | 7.4 (5.1; 107) | 33 | 10.1 (6.7; 14.9) | 303 | 7.3 (4.9; 10.5) |
| FI-OutRef, median (IQR) | 314 | 5 (3; 7) | 33 | 7 (6; 8) | 282 | 5 (3; 7) |
| Change in creatinine and eGFR ** | ||||||
| Δcreatinine inclusion to discharge | 339 | −1.0 (−9.0:7.0) | 33 | −33.0 (−57.0:−13.0) | 306 | 0.0 (−7.0:7.0) |
| ΔeGFR inclusion to discharge | 339 | 1.0 (−4.1:7.1) | 33 | 20.4 (4.4:32.2) | 306 | 0.0 (−4.7:4.9) |
AKI, acute kidney injury; eGFR, estimated glomerular filtration rate calculated with chronic kidney disease epidemiology collaboration (CKD-EPI) equation based on creatinine; CRP, C-reactive protein; IL-6, interleukin 6; TNFα, tumor necrosis factor alpha. * p-values multiplied by seven. ** p-values multiplied by two.