Skip to main content
. 2021 Sep 17;22(18):10055. doi: 10.3390/ijms221810055

Figure 1.

Figure 1

The 2D structures of S-adenosyl-methionine (SAM) (left) and sinefungin (SNF) (right). Substitution at the R group yields sinefungin analog SETD2 inhibitors with micromolar potencies (in the parent compound, the amine is unsubstituted).