Table 1.
Secretory vesicles undergoing exocytosis in astrocytes.
| Secretory Organelle | Diameter | Cargo | Associated Proteins | |
|---|---|---|---|---|
| Protein Name | Gene Name | |||
| Synaptic-Like Microvesicles (SLMVs) | 30–100 nm | Glutamate d-serine |
VGluT1 VGlut2 VGlut3 VAMP2 (synaptobrevin 2) VAMP3 (cellubrevin) Rab3a V-ATPase |
Slc17a7 Slc17a6 Slc17a8 Vamp2 Vamp3 Rab3a Atp6v0, Atp6v1 1 |
| Dense-Core Vesicles (DCV) | 100–600 nm | ANP ATP BDNF Secretogranin II Secretogranin III Chromogranin NPY |
VAMP2 (synaptobrevin 2) VAMP3 (cellubrevin) VNuT |
Vamp2 Vamp3 Slc17a9 |
| Secretory Lysosome (SL) | 300–500 nm | ATP Cathepsin B Cathepsin D Proteolytic enzymes |
VAMP7 (TI-VAMP) Rab7 CD63 LAMP1 Sialin VNuT |
Vamp7 Rab7a Cd63 Lamp1 Slc17a5 Slc17a9 |
1 V-ATPase is a large complex consisting of 13 subunits coded by many more genes; however, all the gene names start with Atp6v0 or with Atp6v1 for the VO and V1 domains, respectively.