Figure 6.

Effects of TiO₂NP exposure on the expression of TXNIP, p-ASK1, t-ASK1, Bax, Bcl2, and cleaved-Cas3 in the lungs. (a) Protein expression was determined using western blotting. (b) Relative densitometric values of protein expression. VC, PBS intranasal instillation; OVA, OVA challenge + PBS intranasal instillation; TiO₂NPs 5, 10, and 20, OVA challenge +5, 10, and 20 mg/kg of TiO₂NPs intranasal instillation, respectively. Data are represented as means ± SD, n = 6. ^# p < 0.05, ^## p < 0.01, significantly different from the VC group; ** p < 0.01, significantly different from the OVA group.