Table 3.
Association of TRIM66 rs112369934 in our measured quantitative phenotypes in gender stratified analysis.
| Gender | Phenotype | Wildtype TT | Variant TC | Mean Difference (95% CI) | p-Value | ||
|---|---|---|---|---|---|---|---|
| N Eyes | Mean (SD) | N Eyes | Mean (SD) | ||||
| Males | MD (dB) | 1492 | −9.38 (9.89) | 158 | −10.83 (10.71) | 1.45 (−0.63 to 3.54) | 0.17 |
| PSD (dB) | 1492 | 5.33 (3.51) | 158 | 5.60 (3.50) | −0.27 (−0.87 to 0.34) | 0.39 | |
| CCT | 1680 | 534.78 (40.80) | 206 | 529.12 (34.40) | 5.66 (−1.27 to 12.59) | 0.11 | |
| CDR | 1737 | 0.73 (0.17) | 210 | 0.77 (0.17) | −0.04 (−0.07 to −0.01) | 0.02 | |
| IOP | 1824 | 17.27 (6.17) | 223 | 17.97 (7.82) | −0.70 (−2.07 to 0.67) | 0.32 | |
| VA.CC | 1548 | 0.43 (0.93) | 183 | 0.53 (0.94) | −0.09 (−0.25 to 0.06) | 0.23 | |
| VA.SC | 1204 | 0.63 (1.09) | 147 | 0.73 (1.10) | −0.10 (−0.32 to 0.12) | 0.38 | |
| RNFL | 1438 | 71.47 (14.84) | 160 | 67.74 (14.88) | 3.73 (0.85 to 6.61) | 0.01 | |
| Females | MD (dB) | 1908 | −7.57 (8.19) | 299 | −7.48 (7.78) | −0.09 (−1.29 to 1.11) | 0.88 |
| PSD (dB) | 1911 | 5.10 (3.44) | 299 | 5.09 (3.34) | 0.00 (−0.49 to 0.50) | 0.99 | |
| CCT | 2281 | 533.15 (39.52) | 372 | 529.89 (37.60) | 3.27 (−2.25 to 8.78) | 0.25 | |
| CDR | 2249 | 0.69 (0.17) | 359 | 0.70 (0.16) | −0.01 (−0.03 to 0.02) | 0.56 | |
| IOP | 2417 | 17.35 (5.87) | 394 | 17.50 (5.91) | −0.15 (−0.94 to 0.64) | 0.72 | |
| VA.CC | 2105 | 0.35 (0.76) | 339 | 0.43 (0.91) | −0.08 (−0.19 to 0.03) | 0.16 | |
| VA.SC | 1587 | 0.52 (0.88) | 227 | 0.66 (1.14) | −0.14 (−0.31 to 0.04) | 0.12 | |
| RNFL | 1963 | 74.82 (14.92) | 315 | 74.59 (15.33) | 0.22 (−2.07 to 2.52) | 0.85 | |
Mean deviation (MD), pattern standard deviation (PSD), central corneal thickness (CCT), cup-to-disc ratio (CDR), intra-ocular pressure (IOP), visual acuity (VA) with correction (CC) and without correction (SC), retinal nerve fiber layer (RNFL).