Figure 1.

Candida tropicalis systemic infection in C57BL/6 mice. Female C57BL/6 mice were infected with 1 × 10⁶ viable C. tropicalis yeasts, and body weight was checked daily (A). The percentage of weight loss (B) was calculated considering the body weight variation between the initial and the final day of the experiment. The animals were evaluated on the 3rd and 19th days for the number of colony forming units per gram of tissue (CFU/g) in the CNS (brain and spinal cord), spleen and kidneys (C). The results are expressed as mean ± SD; n = 6/group (3 days); n = 10/group (19 days); two independent experiments; * p < 0.05 and ** p < 0.01. # Represent significant difference in CFU between kidneys and CNS/spleen samples at 19th day after infection.