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. 2021 Sep 16;13(18):4652. doi: 10.3390/cancers13184652

Figure 3.

Figure 3

Putative and confirmed RNA binding protein motifs on human and murine exon 5 of TF. Depicted is a diagram of F3 and cf3 exon 5, 160 bp each, top and bottom, respectively (adapted from SpliceAid [69]). Green boxes: functionally validated SR protein binding sites that promote exon 5 inclusion (exonic splicing enhancers, ESE), red boxes: functionally validated SR protein binding sites that promote exon 5 exclusion (exonic splicing silencers, ESS). Note the conservation of functional SRSF2 ESS and SRSF6 ESE in human and mouse exon 5 (K.M. and V.Y.B., unpublished data). In italics are putative recognition consensus motifs for various classes of RNA binding proteins; consensus motifs present in human and mouse exon 5 are underlined. Image created with BioRender.com (accessed on 13 September 2021).