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. 2021 Sep 17;11(9):634. doi: 10.3390/metabo11090634

Figure 6.

Figure 6

Upregulation of hepatic GGA level by either oral administration of GGA or GGOH or intraperitoneal administration of ZAA. The content of GGA in the 24-week-old C3H/HeN mouse liver after 1-week oral administration of GGA (0–800 µg/day/mouse) (A) or GGOH (0–8 mg/day/mouse) (B). (C) Time course of hepatic GGA contents in the 24-week-old C3H/HeN mice after the intraperitoneal administration of ZAA. The results are expressed as the mean ± SD (n = 3). * p < 0.05 and ** p < 0.01 versus mice fed a control diet (A,B) or versus untreated mice (C) (ANOVA with post hoc Scheffe). GGA, geranylgeranoic acid; GGOH, geranylgeraniol; ZAA, zaragozic acid A.