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. 2021 Sep 18;13(18):4691. doi: 10.3390/cancers13184691

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Ac-DNMT1 and TIP60 protein levels positive correlate in metastatic melanoma. (A) Comparison of TIP60 mRNA expression using TCGA SKCM dataset. (B) Representative IHC images of TIP60 in the TMA melanoma cohort. Scale bars = 20 μm. (C,D) Correlation between TIP60 and ac-DNMT1 protein levels in stage III (C) and stage IV (D) metastatic FFPE tissues. (E) Comparison of TIP60 H-scores in stage IV patients with high and low ac-DNMT1 protein levels. The best-fit line (straight line) and the 95% CI (dotted line) are shown in grey. Data represent the mean ± SD. ns: not significant, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.

Ac-DNMT1 and TIP60 protein levels positive correlate in metastatic melanoma. (A) Comparison of TIP60 mRNA expression using TCGA SKCM dataset. (B) Representative IHC images of TIP60 in the TMA melanoma cohort. Scale bars = 20 μm. (C,D) Correlation between TIP60 and ac-DNMT1 protein levels in stage III (C) and stage IV (D) metastatic FFPE tissues. (E) Comparison of TIP60 H-scores in stage IV patients with high and low ac-DNMT1 protein levels. The best-fit line (straight line) and the 95% CI (dotted line) are shown in grey. Data represent the mean ± SD. ns: not significant, ** p < 0.01, *** p < 0.001, and **** p < 0.0001.