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. 2021 Sep 18;13(18):4691. doi: 10.3390/cancers13184691

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Ac-DNMT1 and USP7 protein levels positive correlate in metastatic melanoma. (A) Representative IHC images of USP7 in the TMA melanoma cohort. Scale bars = 20 μm. (B,C) Correlation between USP7 and ac-DNMT1 protein levels in stage III (B) or stage IV (C) metastatic FFPE tissues. (D) Comparison of USP7 H-scores in stage IV patients with high or low ac-DNMT1 protein levels. (E) Comparison of USP7 H-scores in normal organ tissues, stage III, and stage IV metastasis from the TMA melanoma cohort. (F,G) Correlation between USP7 and TIP60 protein levels in stage III (F) or stage IV (G) metastatic FFPE tissues. The best-fit line (straight line) and the 95% CI (dotted line) are shown in grey. Data represent the mean ± SD. ns: not significant, * p < 0.05, *** p < 0.001, and **** p < 0.0001.

Ac-DNMT1 and USP7 protein levels positive correlate in metastatic melanoma. (A) Representative IHC images of USP7 in the TMA melanoma cohort. Scale bars = 20 μm. (B,C) Correlation between USP7 and ac-DNMT1 protein levels in stage III (B) or stage IV (C) metastatic FFPE tissues. (D) Comparison of USP7 H-scores in stage IV patients with high or low ac-DNMT1 protein levels. (E) Comparison of USP7 H-scores in normal organ tissues, stage III, and stage IV metastasis from the TMA melanoma cohort. (F,G) Correlation between USP7 and TIP60 protein levels in stage III (F) or stage IV (G) metastatic FFPE tissues. The best-fit line (straight line) and the 95% CI (dotted line) are shown in grey. Data represent the mean ± SD. ns: not significant, * p < 0.05, *** p < 0.001, and **** p < 0.0001.