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. 2021 Aug 29;14(9):874. doi: 10.3390/ph14090874

Figure 3.

Figure 3

Celecoxibaffects proline metabolism in breast cancer cells: (A) prolidase activity after treatment with Cx for 24 h in MCF-7 and MCF-7shPRODH/POX cells; (B)Western blot analysis of proteins related to proline cycle; representative blot images were shown (the mean value of densitometric analysis of protein bands presented below each blot; * p < 0.05, ** p < 0.01, and *** p < 0.001, **** p < 0.0001). Supplementary Materials contain statistical analysis of the evaluated proteins; (C) LC–MS analysis of proline in Cx-treated MCF-7 and MCF-7shPRODH/POX cells after 24 h treatment; (D) collagen biosynthesis after treatment with Cx for 24 h. * p < 0.05, ** p < 0.01, and *** p < 0.001.