Table 4.
Cox regression analysis of risk factors related to in-hospital mortality in COVID-19 patients with respiratory failure.
| Univariable | Adjusted | |||||
|---|---|---|---|---|---|---|
| Variable | HR | 95% CI | p-Value | HR | 95% CI | p-Value |
| Age, years | 1.077 | 0.983–1.180 | 0.113 | 1.023 | 0.942–1.112 | 0.585 |
| Sex, male | 1.622 | 0.405–6.493 | 0.495 | |||
| Initial P/F ratio | 0.999 | 0.993–1.005 | 0.781 | 0.997 | 0.990–1.004 | 0.340 |
| Δ WBC | 1.102 | 0.970–1.251 | 0.136 | |||
| Δ lymphocyte | 0.319 | 0.083–1.227 | 0.096 | 0.741 | 0.096–5.713 | 0.779 |
| Δ Platelet | 0.994 | 0.990–0.999 | 0.019 | 0.993 | 0.986–1.001 | 0.069 |
| Δ LDH (IU/L) | 1.003 | 0.999–1.006 | 0.140 | |||
| Δ Fibrinogen (mg/dL) | 1.001 | 0.999–1.003 | 0.385 | |||
| Δ Ferritin (ng/mL) | 0.999 | 0.997–1.001 | 0.502 | |||
| Δ CRP (mg/L) | 1.003 | 0.996–1.011 | 0.367 | |||
| Δ IL-6/SD | 1.664 | 0.896–3.088 | 0.107 | 1.234 | 0.594–2.564 | 0.573 |
| Δ sIL-2R/SD | 3.145 | 1.177–8.406 | 0.022 | 3.225 | 1.151–9.037 | 0.026 |
Abbreviations: WBC, white blood cell; LDH, lactate dehydrogenase; CRP, C-reactive protein; IL-6, interleukin-6; sIL-2R, soluble interleukin-2 receptor; SD, standard deviation. HR: hazard ratio; CI: confidence interval; Δ: Changes on Day 7 and Day 1