Table 2.
Spaceflight factors-affected biological processes involving matrisome proteins.
| Protein | Uniprot Index | Biological Process (ANDCell) |
|---|---|---|
| Alpha-2-HS-glycoprotein | FETUA_HUMAN | Positive regulation of ECM constituent secretion; Regulation of ECM assembly; erk 1/2 mitogen-activated protein kinase pathway ANG 2; ANG2 expression of ECM proteins; ANG2 erk1/2 pathway; mek/erk pathway; erk pathway |
| Angiotensinogen | ANGT_HUMAN | erk pathway |
| Apolipoprotein A-I | APOA1_HUMAN | erk pathway |
| Apolipoprotein E | APOE_HUMAN | Positive regulation of ECM constituent secretion |
| Carboxypeptidase B2 | CBPB2_HUMAN | erk pathway |
| Cathelicidin antimicrobial peptide | CAMP_HUMAN | ras-erk pathway |
| CD44 antigen | CD44_HUMAN | MMP9 signaling pathway; ras-erk1/2 pathway; mek/erk pathway; erk pathway. |
| Clusterin | CLUS_HUMAN | Inhibition of ECM disassembly; ECM organization; mapk/erk pathway; MMP9 signaling pathway |
| Cystatin-C | CYTC_HUMAN | ECM organization |
| Fibronectin | FINC_HUMAN | ECM organization; Activation of erk pathway; ECM assembly; erk1/2 pathway; Cell–matrix adhesion; erk pathway; Calcium independent cell matrix adhesion; mapk/erk pathway |
| Fibulin-1 | FBLN1_HUMAN | Cell–matrix adhesion |
| Insulin-like growth factor-binding protein 3 | IBP3_HUMAN | erk1/2 pathway |
| Intercellular adhesion molecule 1 | ICAM1_HUMAN | erk1/2 pathway; mek/erk pathway; Cell–matrix adhesion |
| Kininogen-1 | KNG1_HUMAN | Bradykinin in MMP secretion; ECM secretion; mapk/erk pathway |
| Lumican | LUM_HUMAN | ECM assembly |
| Pigment epithelium-derived factor | PEDF_HUMAN | MMP secretion; apoptotic signaling pathway; erk1/2 pathway |
| Transthyretin | TTHY_HUMAN | Apoptotic signaling pathway; erk1/2 pathway |
| Vitronectin | VTNC_HUMAN | ECM organization; Cell–matrix adhesion |