Table 1.
PK parameters which were different for each drug.
| Drug | fu,plasma | Vd (cm3) * | kel (s−1) * | ka (s−1) * | D (ng) | k0 (ng/s) | Rat Weight (g) |
|---|---|---|---|---|---|---|---|
| Amitriptyline | 0.090 a | 4000 c,+ | 7.70 × 10−5 h | 1.54·10−4 # | 5,000,000 h | 250 h | |
| Caffeine | 0.917 b | 180 c,+ | 3.55 × 10−5 i,$ | 833.333 i | 300 i | ||
| Carbamazepine | 0.385 b | 1490.5 d | 4.50 × 10−5 j | 8.99·10−5 # | 3,600,000 j | 300 j | |
| Fleroxacin | 0.793 b | 427.5 e,+ | 7.13 × 10−5 k | 1,114,350 l | 83.125 l | 285 l | |
| Pefloxacin | 0.860 b | 361.1f,+ | 5.83 × 10−5 k | 3,676,500 l | 214.542 l | 285 l | |
| Zolpidem | 0.267 b | 304 g | 1.56 × 10−4 g | 499,700 g | 190 g |
* indicates that the parameter was later adjusted; + indicates that the Vd from the reference was from human data, so it was recalculated for rat; $ this initial estimate corresponds to the α constant rate from the reference; # ka initial estimates were calculated as double the kel initial estimates; a [23], b [24], c [25], d [26], e [27], f [28], g [20], h [16], i [17], j [18], k [29], l [19].