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. 2021 Sep 9;22(18):9763. doi: 10.3390/ijms22189763

Figure 1.

Figure 1

PDBu elicited concentration-dependent constriction of porcine coronary arterioles. (A) The low concentration of PDBu (1 nmol/L) had no effect on vascular tone, but higher concentrations (≥10 nmol/L) caused significant vasoconstrictions (n = 6). * p < 0.05 vs. resting diameter (R), one-way repeated measures ANOVA with Dunnett’s multiple comparison test. (B) PDBu-induced vasoconstriction (PDBu 0.1 µmol/L, n = 5) was prevented by the pan-PKC inhibitor Gö6983 (1 µmol/L, n = 5) but was not affected by the PKCβ2 inhibitor CGP53353 (0.3 µmol/L, n = 5) or Rho kinase inhibitor Y27632 (0.1 µmol/L, n = 5). * p < 0.05 vs. the control, one-way ANOVA with Dunnett’s multiple comparison test.