Table 1.

Clinical details and laboratory findings of patients 1–3 and controls.

Patient	Reaction Onset	Atopy History	Signs and Symptoms	Brighton Level /Vaccine Dose	Treatment	Time of Blood Collection after Onset of Anaphylaxis	Tryptase ng/mL	C3a ug/mL
1	30 min	Asthma, urticaria to etoricoxib	Flushing, periorbital edema, globus sensation, wheezing	1 (Second dose)	IM Adrenaline X 2 doses, IV hydrocortisone, IV diphenhydramine, nebulised salbutamol	3 h	3.2	83.2
						5 weeks	N.A.	58.6
2	30 min	Asthma, allergic rhinitis	Flushing, erythema, breathlessness, globus sensation, wheezing	1 (First dose)	IM adrenaline, IV hydrocortisone, IV diphenhydramine, IV cimetidine, nebulised salbutamol and ipratropium	6 h	2.2	82.1
						41 h	3	81.2
						4 weeks	N.A.	9.0
3	20 min	Chronic rhinosinusitis	Generalised urticaria, periorbital edema, globus sensation, breathlessness	2 (Second dose)	IM adrenaline, IV hydrocortisone and diphenhydramine	6 h	2.3	71.7
						22 h	1.9	28.0
						5 weeks	N.A.	2.5
Vaccine-naive controls (n = 6), Mean ± SD						Not Applicable	N.A.	<10
Vaccine-tolerant controls (n = 6), Mean ± SD						Not Applicable	N.A.	<10

Normal cut-off as follows: Tryptase < 11.4 ng/mL (according to manufacturer’s instructions) Abbreviations: N.A., Not Available; IM, Intramuscular; IV, Intravenous.