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Use of mitochondria for SARS-CoV-2 replication and the release of mt-DNA into the circulation. The figure shows the introduction of SARS-CoV-2 into the host cell (1) and the hijacking of the mitochondrion for its replication (2), causing a loss of its membrane and the release of mt-DNA into the cytosol (3) and circulation (4), activating the immune system (5), and increasing the inflammatory state.
