Table 2.
Minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values determined for coumarin-thiadiazole hybrids and their corresponding Cu(II) and Zn(II) complexes 2–13.
| Compound. | MIC/MBC a [mg/mL] | ||||
|---|---|---|---|---|---|
| Gram-Negative | Gram-Positive | ||||
| E. coli | P. aeruginosa | S. aureus | S. epidermidis ATCC12228 | S. epidermidis ATCC 35984 | |
| 2 | 1.04 | 1.04 | 0.13/2.1 | 0.26 | 0.13/2.1 |
| 3 | 3.12 | 3.12 | 3.12 | 1.56 | 3.12 |
| 4 | 1.56 | 3.12 | 0.78 | 1.56 | 1.56 |
| 5 | 0.78 | 1.56 | 0.19/1.56 | 0.39 | 0.39/1.56 |
| 6 | 4.2 | 4.2 | 4.2 | 2.1 | 4.2 |
| 7 | 4.2 | 4.2 | 4.2 | 4.2 | 4.2 |
| 8 | 5.0 | 5.0 | >5.0 | 5.0 | 2.5 |
| 9 | 3.12 | >3.12 | >3.12 | 0.78 | 0.39 |
| 10 | 3.12 | 1.56 | 3.12 | 1.56 | 3.12 |
| 11 | >5.0 | 5.0 | 5.0 | 5.0 | >5.0 |
| 12 | 3.12 | 6.25 | 3.12 | 3.12 | 1.56 |
| 13 | 1.56 | 1.56 | 0.39 | 0.78 | 0.78 |
| chloramphenicol | 3.9 × 10−3 | 0.25 | 7.8 × 10−3 | 7.8 × 10−3 | 1.56 × 10−2 |
| gentamicin | 1.9 × 10−3 | 1.9 | 0.97 × 10−3 | 0.24 × 10−3 | 3.12 × 10−2 |
| kanamycin | 7.8 × 10−3 | NI | 3.9 × 10−3 | 1.9 × 10−3 | NI |
a—determined only in the tested range of concentrations, which differed for individual compounds (0.13–4.2 mg/mL in compounds: 2, 6, 7; 0.16–5 mg/mL in compounds 8 and 11; 0.19–6.25 mg/mL in compounds: 3, 4, 5, 9, 10, 12, 13).