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. 1999 Oct;19(10):7237–7244. doi: 10.1128/mcb.19.10.7237

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Copyright © 1999, American Society for Microbiology

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FIG. 5 — Exencephaly and growth retardation in a subset of YY1^+/− mice. (A) E13.5 littermates obtained from mixed-strain heterozygous intercrosses (129/Sv × C57BL/6) genotyped as YY1^+/+ on the left and YY1^+/− on the right. The YY1^+/− embryo that is exencephalic with an open brain is shown on the right. (B) A coronal histological section (4-μm thickness) of the exencephalic YY1^+/− embryo observed in panel A stained with hematoxylin and eosin as described in Materials and Methods shows pseudoventricles and asymmetry. (C) An entire litter of E10.5 mice obtained from a YY1^+/− male crossed to a YY1^+/+ wild-type female on the inbred C57BL/6 genetic background. The two smaller embryos in the right-hand corner indicated by arrows were genotyped as YY1^+/− whereas the other embryos were either YY1^+/− or YY1^+/+.