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. 2021 Sep 13;22(18):9880. doi: 10.3390/ijms22189880

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effects of co-application or pretreatment of THI on nicotine-evoked currents. (A,B) show the effect of co-application of 10 µM THI on currents induced by bath application of 10 mM nicotine. (C,D) illustrate currents-evoked by 10 mM nicotine after pretreatment with 10 µM THI. In all histograms, data are mean ± SEM, n = 6 and * p < 0.05. Note that no significant difference was found when in the THI effects with or without 5 min pretreatment. While, (E) represents the inhibition-response curve under co-application of THI with 10 mM nicotine. Each point represents n = 6.