Table A2.
Concordance correlation coefficients (CCC) and their 95% confidence interval (95% CI), and mean differences and their 95% limits of agreement, to report agreement for quantification of usage rate of antimicrobials in feed (in DCDbovCA /100 cow-years) between quantification using feed mills invoices (reference method REF) and quantification using veterinary prescriptions (VET method) or in-person interviews of dairy producers (FARM method), by antimicrobial, category (medically important antimicrobials, MIA, or non-MIA), and totally, from a sample of 101 dairy farms from Québec, Canada.
| Antimicrobial Agent(s) | REF vs. VET | REF vs. FARM | ||
|---|---|---|---|---|
| CCC (95% CI) | Mean Difference (95% Limits of Agreement) | CCC (95% CI) | Mean Difference (95% Limits of Agreement) | |
| Monensin | 0.68 (0.57, 0.76) | −19 (−303, 265) | 0.72 (0.61, 0.80) | −19 (−312, 274) |
| Lasalocid | 0.37 (0.27, 0.47) | 4 (−58, 66) | 0.66 (0.65, 0.67) | 2 (−45, 50) |
| Decoquinate | 0.41 (0.29, 0.52) | 5 (−68, 78) | 0.43 (0.38, 0.49) | −6 (−37, 25) |
| Chlortetracycline 1 | 0.73 (0.63, 0.81) | 3 (−37, 43) | 0.54 (0.50, 0.57) | −2 (−36, 32) |
| Oxytetracycline 1 | 0.38 (0.31, 0.44) | 7 (−108, 122) | 0.20 (0.17, 0.22) | −2 (−37, 32) |
| Neomycin sulfate 1 | 0.00 (−0.08, 0.07) | 2 (−54, 59) | 0.70 (0.69, 0.71) | 0 (−7, 6) |
| Streptomycin sulfate 1 | 2 | 0 (−1, 2) | 2 | 0 (0, 0) |
| Benzylpenicillin 1 | 2 | 0 (−1, 2) | 2 | 0 (0, 0) |
| Sulfamethazine 1 | 0.73 (0.62, 0.80) | 1 (−6, 8) | 0.52 (0.51, 0.54) | 0 (−7, 6) |
| Combined trimethoprim and sulfadiazine 1 | NE | NE | NE | NE |
| Total, non-MIA | 0.63 (0.50, 0.73) | −10 (−321, 301) | 0.71 (0.59, 0.79) | −23 (−321, 274) |
| Total, MIA | 0.43 (0.31, 0.54) | 13 (−127, 154) | 0.50 (0.46, 0.54) | −5 (−66, 57) |
| Total | 0.68 (0.57, 0.77) | 3 (−312, 319) | 0.75 (0.65, 0.82) | −28 (−310, 254) |
1 Medically important antimicrobials (MIA) according to the World Health Organization [5]. 2 Antimicrobials for which both methods perfectly agreed and reported a usage of 0 kg/100 cow-years for all farms. In such cases, a CCC could not be computed. NE: no estimate (quantities not reported in DCDbovCA /100 cow-years).