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. 2021 Sep 1;10(9):1058. doi: 10.3390/antibiotics10091058

Table 1.

Helicobacter pylori antimicrobial resistance trends between 2013 and 2020 in naïve patients.

Resistance Years—Number of Patients (%) Total
2013 2014 2015 2016 2017 2018 2019 2020
No resistance 209 (49%) 260 (50%) 245 (49%) 120 (44%) 188 (55%) 135 (48%) 130 (48%) 78 (36%) 1365 (48%)
Clarithromycin 85 (20%) 119 (23%) 136 (27%) 91 (34%) 83 (24%) 76 (27%) 76 (28%) 35 (16%) 701 (25%)
Metronidazole 165 (39%) 155 (30%) 162 (32%) 90 (33%) 84 (25%) 78 (28%) 77 (29%) 40 (18%) 852 (30%)
Levofloxacin 58 (14%) 100 (19%) 121 (24%) 73 (27%) 75 (22%) 69 (25%) 48 (18%) 16 (7%) 561 (20%)
Amoxicillin 6 (1%) 0 (0%) 0 (0%) 0 (0%) 4 (1.2%) 1 (0.4%) 0 (0%) 0 (0%) 11 (0,4%)
Tetracycline 2 (0.5%) 1 (0.2%) 0 (0%) 1 (0.4%) 0 (0%) 0 (0%) 1 (0.4%) 0 (0%) 5 (0,2%)
Dual (C+M) 56 (13%) 64 (12%) 77 (15%) 45 (17%) 41 (12%) 34 (12%) 35 (13%) 16 (7%) 368 (13%)
Triple (C+M+L) 22 (5%) 31 (6%) 45 (9%) 26 (10%) 19 (5.5%) 19 (6%) 11 (4%) 2 (0.9%) 172 (6%)

C—clarithromycin; M—metronidazole; L—levofloxacin.