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. 2021 Sep 18;13(9):1506. doi: 10.3390/pharmaceutics13091506

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© 2021 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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CAR-DCN treatment of mdxD2 mice significantly decreased membrane permeability in the two muscle types analyzed. Three week-old mdxD2 mice were treated with CAR-DCN, decorin (DCN), mutant CAR-DCN (mCAR-DCN), or PBS for a period of three weeks, and were then assessed by skeletal muscle Evans blue dye (EBD) uptake normalized to kidney EBD uptake. Abs, abdominals; Quads, quadriceps; Hams, hamstring. Data represent mean ± SEM. Solid lines indicate statistical significance (p < 0.05). n = 7, 11, 10, 10 animals, respectively.